Human infections with Salmonella enterica results in two major groups of diseases: gastroenteritis and typhoid fever.Clinical observations suggest that gastroenteritis, caused by non-typhoidal Salmonella serovars, is characterized by a massive neutrophil influx, which keeps the infection localized to the intestinal mucosa.In contrast, the absence of neutrophilic 15-fc0093dx intestinal infiltrates in the acute phase of typhoid fever suggests a propensity for typhoidal Salmonella serovars (S.
Typhi, S.Paratyphi A, S.Paratyphi B and S.
Paratyphi C) to evade aspects of the innate immune response and cause a systemic infection.The fact that there are no buderim glace ginger virulence genes shared by typhoidal Salmonella serovars that are absent from non-typhoidal Salmonella serovars, suggests that this innate immune evasion is mediated by different mechanisms in different typhoidal serovars.This review discusses what is known about the clinical pathogenesis of typhoid fever.